Isoket IV Dosage/Direction for Use

This medicinal product is a concentrated solution and must be diluted prior use. The diluted solution should never be injected directly in the form of a bolus.
Isosorbide dinitrate solution for infusion or injection can be administered as an intravenous admixture with a suitable vehicle (see Use and Handling under Cautions for Usage).
Prepared isosorbide dinitrate admixtures should be given by intravenous infusion or with the aid of a syringe pump incorporating a glass or rigid plastic syringe. During administration, the patient's blood pressure and pulse should be closely monitored and dose adjusted according to the patient's response.
Route of Administration: For intravenous use.
Adults: A dose of between 2 mg and 12 mg per hour is usually satisfactory.
However, dosages up to 20 mg per hour administered should be adjusted to the patient's response.
Children: The safety and efficacy of isosorbide dinitrate solution for infusion or injection has not yet been established in children.
Elderly: No dose adjustment is necessary.
Renal and Hepatic impairment: Isosorbide dinitrate should be used with caution in patients with severely impaired renal or hepatic function (see Precautions).